IPSS Score
|
|
| Bone Marrow Blasts (%) |
|
| Karyotype |
|
| Cytopenias |
|
Cytopenias: Neutrophils < 1.5 x 109/L, Platelets < 100 x 109/L, Hemoglobin < 10 g/L ( 6.2 mM).
All patients (n=816):
|
Risk group
|
Score
|
Median survival
(years)
|
Time to AML transformation
(for 25% in years)
|
|
Low risk
|
0
|
5.7
|
9.4
|
|
INT-1
|
0.5-1.0
|
3.5
|
3.3
|
|
INT-2
|
1.5-2.0
|
1.2
|
1.1
|
|
High risk
|
≥2.5
|
0.4
|
0.2
|
Patients below age 60 (n=205):
|
Risk group
|
Score
|
Median survival
(years)
|
Time to AML transformation
(for 25% in years)
|
|
Low risk
|
0
|
11.8
|
>9.4
|
|
INT-1
|
0.5-1.0
|
5.2
|
6.9
|
|
INT-2
|
1.5-2.0
|
1.8
|
0.7
|
|
High risk
|
≥2.5
|
0.3
|
0.2
|
Reference: Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997; 89: 2079-2088.
