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default Ex Vivo expanded adaptive NK cells effectively kill primary acute lymphoblastic leukemia cells (196 downloads)
default SF3B1-initiating Mutations in MDS with ring sideroblasts target lymphomyeloid hematopoietic stem cells (192 downloads)
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (191 downloads)
default Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance (159 downloads)
default Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease (157 downloads)
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (225 downloads)
default Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel (298 downloads)
default Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome (183 downloads)
default Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations (156 downloads)
default Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice (251 downloads)
default Evaluating variant calling tools for non-matched next-generation sequencing data (224 downloads)
default Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia (215 downloads)
default Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality (351 downloads)
default GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (455 downloads)
default Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes (177 downloads)
default Mutations in histone modulators are associated with prolonged survival during azacitidine therapy (605 downloads)
default The European Hematology Association Roadmap for European Hematology Research: a consensus document (213 downloads)
default Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts (539 downloads)
default Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome (353 downloads)
default Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry (466 downloads)
default SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts (674 downloads)
default Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (122 downloads)
default High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia (495 downloads)
default Self-perception of symptoms of anemia and fatigue before and after blood transfusions in patients with myelodysplastic syndromes (534 downloads)
default Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes (186 downloads)
default Specific scoring systems to predict survival of patients with high-risk myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) after intensive antileukemic treatment based on results of the EORTC-GIMEMA AML-10 and intergroup CRIANT studie (394 downloads)
default Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes (137 downloads)
default Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study (501 downloads)
default Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia (168 downloads)
default Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes (152 downloads)
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (658 downloads)
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (162 downloads)
default A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine (526 downloads)
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (160 downloads)
default p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q) (128 downloads)
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (631 downloads)
pdf Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial (532 downloads)
default Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation (496 downloads)
default Cardiac iron overload assessed by T2* magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients (457 downloads)
default Challenges of phase III trial design for novel treatments in diseases with no standard treatment: the AZA-001 myelodysplasia study model (118 downloads)
default Clinical and biological implications of driver mutations in myelodysplastic syndromes (640 downloads)
default Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet (179 downloads)
default Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes (470 downloads)
default Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis (120 downloads)
default A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial (108 downloads)
default Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions (160 downloads)
default The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts (171 downloads)
default Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis (114 downloads)
default Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1 (162 downloads)
default Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group (106 downloads)
default Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes (173 downloads)
default Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q (104 downloads)
pdf Evaluation of Azacitidine in transfusion-dependent, Epo-refractory patients with lower-risk MDS ( pdf, 83 KB ) (697 downloads)
default Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML (174 downloads)
default Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms (162 downloads)
default Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks (120 downloads)
default Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts (149 downloads)
default Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome (149 downloads)
default Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes (97 downloads)
default TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression (160 downloads)
pdf Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities (459 downloads)
default Effects of azacitidine compared with conventional care regimens in elderly (≥ 75 years) patients with higher-risk myelodysplastic syndromes (105 downloads)
pdf Significance of JAK2 and TET2 mutations in myelodysplastic syndromes (600 downloads)
default Persistent malignant stem cells in del(5q) myelodysplasia in remission (161 downloads)
default Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine (99 downloads)
pdf Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy (462 downloads)
default Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C (98 downloads)
default Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia (114 downloads)
default Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression (98 downloads)
pdf Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study (464 downloads)
pdf Erythropoietin and G-CSF treatment associated with improved survival in myelodysplastic syndrome (504 downloads)
pdf Supportive care, growth factors, and new therapies in myelodysplastic syndromes (507 downloads)
default Azacitidine prolongs overall survival and reduces infections and hospitalizations in patients with WHO-defined acute myeloid leukaemia compared with conventional care regimens: an update (105 downloads)
default The effects of continued azacitidine treatment cycles on response in higher risk patients with myelodysplastic syndromes: an update (101 downloads)
pdf Negative Effect of DNA Hypermethylation on the Outcome of Intensive Chemotherapy in Older Patients with High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia following Myelodysplastic Syndrome (336 downloads)
default The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes (101 downloads)
pdf Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes (417 downloads)
default Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations (98 downloads)
default Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes (101 downloads)
pdf Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF (472 downloads)
pdf The WHO classification of MDS does make a difference (448 downloads)
pdf No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease (413 downloads)
pdf A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life (429 downloads)
default Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8 (98 downloads)
default Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level (106 downloads)