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default Male sex and the pattern of recurrent myeloid mutations are strong independent predictors of blood transfusion intensity in patients with myelodysplastic syndromes. (889 downloads)
default TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups. (893 downloads)
default A three-dimensional in vitro model of erythropoiesis recapitulates erythroid failure in myelodysplastic syndromes. (875 downloads)
default Nordic Guidelines for Germline Predisposition to Myeloid Neoplasms in Adults: Recommendations for Genetic Diagnosis, Clinical Management and Follow-up. (851 downloads)
default Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes. (977 downloads)
default Myelodysplastic syndromes: moving towards personalized management. (948 downloads)
default Prognostic scoring systems and comorbidities in chronic myelomonocytic leukaemia: a nationwide population-based study. (819 downloads)
default SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS. (989 downloads)
default Clonal hematopoiesis in elderly twins: concordance, discordance and survival. (961 downloads)
default Improved Outcomes after Allogenic Hematopoietic Stem Cell Transplantation with Fludarabine/Treosulfan for Patients with Myelodysplastic Syndromes. (928 downloads)
default Clonal hematopoiesis evolves from pre-treatment clones and stabilizes after end of chemotherapy in patients with MCL (834 downloads)
default Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity are Linked to Clinical Responses to 5-Azacytidine. (899 downloads)
default Clinical impact of clonal hematopoiesis in patients with lymphoma undergoing ASCT: A national population-based cohort study (871 downloads)
default Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations (1538 downloads) Popular
default Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. (1495 downloads) Popular
default Prognostic scoring systems for myelodysplastic syndromes (MDS) in a population-based setting: a report from the Swedish MDS register. (1571 downloads) Popular
default Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. (1337 downloads) Popular
default Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study. (1389 downloads) Popular
default Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. (1431 downloads) Popular
default Prognostic impact of a suboptimal number of analyzed metaphases in normal karyotype lower-risk MDS. (1408 downloads) Popular
default Megakaryocytes harbour the del(5q) abnormality despite complete clinical and cytogenetic remission induced by lenalidomide treatment. (1324 downloads) Popular
default Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes. (1397 downloads) Popular
default Gene expression and risk of leukemic transformation in myelodysplasia. (1365 downloads) Popular
default Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes. (1386 downloads) Popular
default Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q). (1320 downloads) Popular
default Ex Vivo expanded adaptive NK cells effectively kill primary acute lymphoblastic leukemia cells (1667 downloads) Popular
default SF3B1-initiating Mutations in MDS with ring sideroblasts target lymphomyeloid hematopoietic stem cells (1525 downloads) Popular
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (1623 downloads) Popular
default Cytomorphology review of 100 newly diagnosed lower-risk MDS patients in the European LeukemiaNet MDS (EUMDS) registry reveals a high inter-observer concordance (1494 downloads) Popular
default Comprehensive mapping of the effects of azacitidine on DNA methylation, repressive/permissive histone marks and gene expression in primary cells from patients with MDS and MDS-related disease (1553 downloads) Popular
default The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes (1595 downloads) Popular
default Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel (1754 downloads) Popular
default Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome (1485 downloads) Popular
default Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations (1547 downloads) Popular
default Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice (1591 downloads) Popular
default Evaluating variant calling tools for non-matched next-generation sequencing data (1536 downloads) Popular
default Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia (1653 downloads) Popular
default Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality (1573 downloads) Popular
default GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome (1792 downloads) Popular
default Impact of socioeconomic status on disease phenotype, genomic landscape and outcomes in myelodysplastic syndromes (1403 downloads) Popular
default Mutations in histone modulators are associated with prolonged survival during azacitidine therapy (1920 downloads) Popular
default The European Hematology Association Roadmap for European Hematology Research: a consensus document (1576 downloads) Popular
default Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts (1760 downloads) Popular
default Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome (1637 downloads) Popular
default Validation of the revised international prognostic scoring system (IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS (EUMDS) registry (1734 downloads) Popular
default SF3B1 mutation identifies a distinct subset of myelodysplastic syndrome with ring sideroblasts (2041 downloads) Popular
default Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells (1200 downloads) Popular
default High-throughput mutational screening adds clinically important information in myelodysplastic syndromes and secondary or therapy-related acute myeloid leukemia (1686 downloads) Popular
default Self-perception of symptoms of anemia and fatigue before and after blood transfusions in patients with myelodysplastic syndromes (1859 downloads) Popular
default Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes (1294 downloads) Popular
default Specific scoring systems to predict survival of patients with high-risk myelodysplastic syndrome (MDS) and de novo acute myeloid leukemia (AML) after intensive antileukemic treatment based on results of the EORTC-GIMEMA AML-10 and intergroup CRIANT studie (1527 downloads) Popular
default Minimal morphological criteria for defining bone marrow dysplasia: a basis for clinical implementation of WHO classification of myelodysplastic syndromes (1273 downloads) Popular
default Outcomes in RBC transfusion-dependent patients with Low-/Intermediate-1-risk myelodysplastic syndromes with isolated deletion 5q treated with lenalidomide: a subset analysis from the MDS-004 study (1719 downloads) Popular
default Driver somatic mutations identify distinct disease entities within myeloid neoplasms with myelodysplasia (1419 downloads) Popular
default Differential methylation in CN-AML preferentially targets non-CGI regions and is dictated by DNMT3A mutational status and associated with predominant hypomethylation of HOX genes (1264 downloads) Popular
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (1849 downloads) Popular
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (1284 downloads) Popular
default A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine (1654 downloads) Popular
default A mutation in the H/ACA box of telomerase RNA component gene (TERC) in a young patient with myelodysplastic syndrome (1317 downloads) Popular
default p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q) (1365 downloads) Popular
default Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo (1897 downloads) Popular
pdf Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial (1769 downloads) Popular
default Azacitidine induces profound genome-wide hypomethylation in primary myelodysplastic bone marrow cultures but may also reduce histone acetylation (1623 downloads) Popular
default Cardiac iron overload assessed by T2* magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients (1628 downloads) Popular
default Challenges of phase III trial design for novel treatments in diseases with no standard treatment: the AZA-001 myelodysplasia study model (1277 downloads) Popular
default Clinical and biological implications of driver mutations in myelodysplastic syndromes (2062 downloads) Popular
default Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet (1355 downloads) Popular
default Identification of gene expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes (1604 downloads) Popular
default Role of reduced-intensity conditioning allogeneic hematopoietic stem-cell transplantation in older patients with de novo myelodysplastic syndromes: an international collaborative decision analysis (1159 downloads) Popular
default A multivariate analysis of the relationship between response and survival among patients with higher-risk myelodysplastic syndromes treated within azacitidine or conventional care regimens in the randomized AZA-001 trial (1191 downloads) Popular
default Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions (1330 downloads) Popular
default The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts (1148 downloads) Popular
default Lenalidomide does not increase AML progression risk in RBC transfusion-dependent patients with Low- or Intermediate-1-risk MDS with del(5q): a comparative analysis (1223 downloads) Popular
default Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1 (1221 downloads) Popular
default Rationale for the clinical application of flow cytometry in patients with myelodysplastic syndromes: position paper of an International Consortium and the European LeukemiaNet Working Group (1063 downloads) Popular
default Bone marrow dendritic cells are reduced in patients with high-risk myelodysplastic syndromes (1423 downloads) Popular
default Downregulation but lack of promoter hypermethylation or somatic mutations of the potential tumor suppressor CXXC5 in MDS and AML with deletion 5q (1274 downloads) Popular
pdf Evaluation of Azacitidine in transfusion-dependent, Epo-refractory patients with lower-risk MDS ( pdf, 83 KB ) (1986 downloads) Popular
default Allelic methylation levels of the noncoding VTRNA2-1 located on chromosome 5q31.1 predict outcome in AML (1255 downloads) Popular
default Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms (1285 downloads) Popular
default Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks (1197 downloads) Popular
default Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts (1188 downloads) Popular
default Marked down-regulation of nucleophosmin-1 is associated with advanced del(5q) myelodysplastic syndrome (1158 downloads) Popular
default Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes (1086 downloads) Popular
default TP53 mutations in low-risk myelodysplastic syndromes with del(5q) predict disease progression (1242 downloads) Popular
pdf Clinical effect of increasing doses of lenalidomide in high-risk myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities (1511 downloads) Popular
default Effects of azacitidine compared with conventional care regimens in elderly (≥ 75 years) patients with higher-risk myelodysplastic syndromes (1172 downloads) Popular
pdf Significance of JAK2 and TET2 mutations in myelodysplastic syndromes (1693 downloads) Popular
default Persistent malignant stem cells in del(5q) myelodysplasia in remission (1264 downloads) Popular
default Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine (1308 downloads) Popular
pdf Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy (1484 downloads) Popular
default Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C (1169 downloads) Popular
default Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia (1199 downloads) Popular
default Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression (1106 downloads) Popular
pdf Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study (1605 downloads) Popular
pdf Erythropoietin and G-CSF treatment associated with improved survival in myelodysplastic syndrome (1666 downloads) Popular
pdf Supportive care, growth factors, and new therapies in myelodysplastic syndromes (1624 downloads) Popular
default Azacitidine prolongs overall survival and reduces infections and hospitalizations in patients with WHO-defined acute myeloid leukaemia compared with conventional care regimens: an update (1156 downloads) Popular
default The effects of continued azacitidine treatment cycles on response in higher risk patients with myelodysplastic syndromes: an update (1128 downloads) Popular
pdf Negative Effect of DNA Hypermethylation on the Outcome of Intensive Chemotherapy in Older Patients with High-Risk Myelodysplastic Syndromes and Acute Myeloid Leukemia following Myelodysplastic Syndrome (1430 downloads) Popular
default The molecular signature of MDS stem cells supports a stem-cell origin of 5q myelodysplastic syndromes (1051 downloads) Popular
pdf Antithymocyte globulin and cyclosporine A as combination therapy for low-risk non-sideroblastic myelodysplastic syndromes (1373 downloads) Popular
default Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations (1028 downloads) Popular
default Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes (1005 downloads) Popular
pdf Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF (1503 downloads) Popular
pdf The WHO classification of MDS does make a difference (1466 downloads) Popular
pdf No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease (1325 downloads) Popular
pdf A validated decision model for treating the anaemia of myelodysplastic syndromes with erythropoietin + granulocyte colony-stimulating factor: significant effects on quality of life (1382 downloads) Popular
default Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8 (1065 downloads) Popular
default Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level (1044 downloads) Popular

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